Speaking to the BBC, Chris Sutton said: "Paul Heckingbottom's departure as Sheffield United manager is official, and it's not exactly be surprising to see him go after their past couple of results against Bournemouth and Burnley.
"A new voice makes the first game after a change of manager really interesting. But, with Chris Wilder getting the job, I don't see it making much difference for the Blades, because what worries me is how brittle they are at the back.
"Liverpool did amazingly well to come back to beat Fulham and they are right in the thick of the title race now. This should be a much more straightforward victory for Jurgen Klopp's side, who have got the firepower to win comfortably."
Sutton's prediction: Sheffield Utd 0–3 Liverpool
With Arsenal beating Luton Town on Tuesday, Liverpool need to secure a positive result away at Sheffield United on Wednesday to keep up in the title race.
The Reds understand that they can't afford to drop points against the Blades with Manchester City guaranteed to kick into full gear sooner or later.
